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Effect of antiinflammatory drugs in the therapy of male infertility How alcohol affects sperm and male fertility ; in men, heavy drinking affects ; combining drugs like marijuana or opioids. It is known that immunosuppressive drugs can affect male sexual health and reproduction via multiple mechanisms: by altering reproductive. That can affect male fertility include alcohol, tobacco, and illicit drugs. Over-the-counter medicines can have a negative impact on male fertility. We give you 5 common otc's that can affect male fertility. Conditions of the male that affect fertility are still generally. Varicocoeles may cause reduced sperm count and abnormal sperm morphology which cause infertility. Variococles can usually be diagnosed by a physical examination. Medication can improve sperm count in some men with infertility. Your doctor may prescribe an estrogen receptor blocker, such as clomiphene citrate, which. Conclude that thc negatively affects male reproductive physiology (table 2). 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